ea0011p553 | Growth and development | ECE2006
Filisetti M
, Mella P
, Pilotta A
, Costa L
, Sparapani I
, Zanola S
, Guaragni B
, Felappi B
, Prandi E
, Buzi F
GH acts at the target cell through the GH receptor (GHR), stimulating a cascade of events that leads to target gene transcription. Polymorphisms of the GHR (GHRPs) have been reported in the general population and have been described in exons 3, 6 and 10, although their prevalence is not well defined. It is conceivable that GHRPs might affect the growth response to exogenous GH in children with short stature of different origin. To evaluate the prevalence of the different GHRPs...